Whole-Genome Sequencing Clinical Trials for Triple-Negative Breast Cancer

by Kathy Jones on  December 4, 2011 at 7:01 PM Clinical Trials News
RSS Email Print This Page Comment
Previous research has shown that triple negative breast tumors make up nearly 20 percent of breast cancers. These cancers do not respond to treatment with targeted therapies such as HerceptinŪ (trastuzumab).
 Whole-Genome Sequencing Clinical Trials for Triple-Negative Breast Cancer
Whole-Genome Sequencing Clinical Trials for Triple-Negative Breast Cancer

To investigate new options for these patients, the first clinical trial of whole-genome sequencing for women with triple negative breast cancer was initiated in March 2010, and the first results will be presented during the 2011 CTRC-AACR San Antonio Breast Cancer Symposium, Dec. 6-10, 2011.

Based on mutations uncovered by sequencing, physicians steered the women into treatment protocols for either existing drugs or new agents being evaluated in pharma-sponsored clinical trials. Several patients displayed benefit from treatments physicians selected taking sequencing data into consideration.

Results will be presented at 10:30 am CST, Thursday, Dec. 8, by Joyce O'Shaughnessy, M.D., medical director and co-chair of the Breast Cancer Research Committee, US Oncology Research; a practicing oncologist with Texas Oncology; and the Celebrating Women Chair of Breast Cancer Research at Baylor Charles A. Sammons Cancer Center.

The study, titled "Next Generation Sequencing Reveals Co-Activating Events in the MAPK and PI3K/AKT Pathways in Metastatic Triple Negative Breast Cancers," is sponsored by the Translational Genomics Research Institute (TGen) and US Oncology Research with support from Life Technologies Corporation (NASDAQ:LIFE - News).



Source: Eurekalert

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
* Your comment can be maximum of 2500 characters
Notify me when reply is posted
I agree to the terms and conditions

Related Links

More News on:

Women and Cancer Pagets disease of the breast Mastitis Clinical Trials Cancer and Homeopathy Clinical Trials - The Past and The Future Clinical Trials - Different Phases of the trial Breast Cancer Facts Cancer Facts Cancer 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.


Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

News Category

News Archive