A new study has offered a novel way to determine what biological functions go awry when-Glioblastoma-the most common and most lethal form of brain tumor in people first begins to form.
Scientists behind the research believe that understanding the problems at the molecular level might one day reveal the underlying mechanism of carcinogenesis in glioblastoma and ultimately lead to treatments or even preventative measures.
Zhongming Zhao and colleagues at Vanderbilt University, in Tennessee, explain how problems that occur during the transcription of the genetic code for making proteins may play a role in the formation of a glioblastoma.
These might arise through changes in the genetic materials itself or alterations to the molecules involved in regulating the transcription process.
"Our work provided data for future investigation of the mechanisms underlying glioblastoma and also potential regulatory subunits that might be useful for biomarker discovery and therapy targets for glioblastoma," the team concludes.
The study has been published in the International Journal of Computational Biology and Drug Design.