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Weight-based Dosage Increases Hepatitis C Treatment Efficacy
She added: "Our findings underscore that weight-based-dosed combination therapy is significantly more effective than the flat-dosed RBV regimen, especially in more difficult-to-treat patient groups, such as patients with genotype 1 and African-American patients. Patients being treated for hepatitis C should talk to their doctors to be sure they are receiving the most effective therapy."
According to a subanalysis of the WIN-R data evaluating the efficacy of weight-based dosing among African-American participants with genotype 1 infection, about twice the number of patients cleared the virus when treated with the weight-based RBV regimen as against the flat dose. Also, a lower rate was shown in the general study population with genotype 1 HCV.
"These results are particularly significant for African-Americans, a group with known lower rates of response to HCV therapy than reported in other ethnic groups. Weight-based dosing vs. flat dosing clearly showed the greatest therapeutic impact in this group," said Dr. Jacobson.
She added: "The study data strongly suggest adopting a 1400 mg/dose for patients who weigh more than 105 kg. In my opinion, the larger dose provides an opportunity for very heavy patients to have the same chance of cure as lighter patients without compromising safety.”
The study is reported recently in the journal Hepatology.
Source-ANI
LIN/M
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More News on: Hepatitis A, Hepatitis B, Vasculitis , Silent Killer Diseases, Liver, Aplastic Anemia, Hepatitis C
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