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Weight-based Dosage Increases Hepatitis C Treatment Efficacy

by Sreeraman on December 28, 2007 at 7:32 PM Drug News

A multicenter study called WIN-R on hepatitis C patients, showed that the treatment with weight-based drugs resulted in improved efficacy and lower relapse rates, mainly in African-Americans with most difficult-to-treat form of the disease.

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The study of over 5,000 patients with hepatitis C virus (HCV) showed that the treatment with weight-based REBETOL (ribavirin, USP) (RBV) in combination with pegylated interferon (PEG-IFN) alfa-2b, resulted in higher rates of sustained virologic response (SVR) and lower relapse rates, as compared to combination therapy using a flat dose of RBV 800 mg/day.

The response of such dose was a lot better in patients suffering from the most difficult-to-treat form of the disease, genotype 1 HCV.

However, the efficacy was consistent across all weight groups.

The study was led by Dr. Ira M. Jacobson, the Vincent Astor Professor of Clinical Medicine at Weill Cornell Medical College and chief of the Division of Gastroenterology and Hepatology at NewYork-Presbyterian Hospital/Weill Cornell Medical Center.

For patients infected with genotype 2 or 3, a 24-week course of treatment with flat dose of RBV + PEG-IFN was equally effective as the standard 48-week course, with better tolerability.

In the overall study population, flat dosing of ribavirin was equally effective as weight-based ribavirin.

However, within the flat-dose group of patients with genotypes 2 and 3, sustained response rates showed a slight decline in the higher weight patients who were given flat-dosed ribavirin.

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Weight-based Dosage Increases Hepatitis C Treatment Efficacy

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