Vitamin D Genetic Variant Linked to Skin Cancer Risk

by VR Sreeraman on  September 22, 2008 at 6:30 PM Cancer News   - G J E 4
 Vitamin D Genetic Variant Linked to Skin Cancer Risk
Individuals with certain variants in a gene involved in vitamin D metabolism might be at an increased risk of developing melanoma, according to a new study.

University of Padova researchers in Italy have found that a variant of Bsml gene, involved in vitamin D metabolism, may be linked to skin cancer.

Previous studies have shown that vitamin D in the body has significant protective effects against the development of cancer because it regulates cell growth, cell differentiation and cell death. It exerts its effects by binding to a receptor located within cells.

But owing to the genetic differences in this vitamin D receptor among individuals, investigators believe that different people have different levels of vitamin D activity within their bodies. Therefore, some individuals may naturally be able to achieve more vitamin D-related protection against cancer than others.

During the study, lead researchers Simone Mocellin and Donato Nitti reviewed the existing research investigating the association between common variants in the vitamin D receptor and the risk of melanoma.

Their analysis showed a significant association between melanoma risk and the BsmI gene.

"These findings prompt further investigation on this subject and indirectly support the hypothesis that sun exposure might have an anti-melanoma effect through activation of the vitamin D system," the authors wrote.

The study is reported in the November 1, 2008 issue of Cancer.

Source: ANI

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

View All