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Virus Could Behave Like a 'Late-life-acting' Biopesticide Against Malaria

by Savitha.C.Muppala on August 24, 2010 at 12:30 PM Tropical Disease News

A virus that occurs naturally in mosquitoes could behave like a "late-life-acting" insecticide and destroy older adult mosquitoes that have a big role to play in malaria transmission.

Virus Could Behave Like a 'Late-life-acting' Biopesticide Against Malaria

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Malaria infects hundreds of thousands of people each year and is the cause of over a million deaths worldwide. Insecticides are one of the main strategies currently used to control malaria transmission, however, evolving resistance to such therapies continues to impact such efforts.

"Late-life-acting" insecticides (LLAIs) are now being examined as a new approach for controlling malaria as they selectively kill older mosquitoes that spread the disease, while younger mosquitoes survive just long enough to reproduce.

"Reproduction allows for relaxation of evolutionary pressures that select for resistance to the agent. If resistance alleles exert fitness costs, there are theoretical scenarios under which resistance is not expected to evolve, leading some to provocatively term LLAIs as 'evolution-proof,'" said the researchers.

Densonucleosis viruses (or densoviruses [DNVs]) are naturally occurring parvoviruses that have been identified in multiple mosquito species.

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Virus Could Behave Like a 'Late-life-acting' Biopesticide Against Malaria

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