A study published in Lancet Neurology has found that treating 'brain tsunamis' or 'killer waves' could stop many victims of major head injury from suffering additional brain damage.
Scientists have been investigating this phenomenon for decades, with the topic of spreading depolarizations now of keen interest to the U.S. military because head injuries have emerged as the signature wound of the wars in Iraq and Afghanistan.
AdvertisementResearchers at King's College London and King's College Hospital in collaboration with colleagues at the University of Cincinnati (UC) found that of 103 patients undergoing neurosurgery following major head trauma, 58 experienced a phenomenon called cortical spreading depolarizations, or 'brain tsunamis.'
The Lancet study supports the original clinical evidence that brain tsunamis are common in patients with major brain injuries, and now shows - for the first time - that they contribute to worse outcomes in these patients. Longer-term, it is hoped the results of this study will be used to help guide how brain injuries are treated and managed, leading to better outcomes for patients.
The majority of patients were treated at King's College Hospital in London. Nine were treated at UC Health/University Hospital. Patients were enrolled at seven centres internationally, including the University of Miami, University of Pittsburgh, Virginia Commonwealth University, and the German centres Charité University Medicine (Berlin) and University Hospital Heidelberg. The collaborating scientists and clinicians are members of COSBID (Co-Operative Studies of Brain Injury Depolarizations: http://www.cosbid.org).
Professor Anthony Strong, King's College London, who led the study in the UK, said the results were promising:
'This is an exciting area of research, which is attracting a lot of interest and collaboration internationally. This study provides real, concrete evidence that brain tsunamis can cause further damage to the brain in the few days after a major injury. This is significant, because they have a direct link to poor recovery in patients. Of course, the end goal is to take the results of this study and, longer term, develop new treatments for this type of injury. This potentially may mean finding a way of blocking these killer waves as they are happening.'
Principal investigator Jed Hartings, PhD, research assistant professor in the department of neurosurgery at the UC College of Medicine and director of clinical monitoring for the Mayfield Clinic, emphasized the historical nature of the findings: 'Spreading depolarizations were first discovered in animals almost 60 years ago and for a long time were thought to not occur in the human brain. We didn't begin studying them in patients until recently, partly because we didn't know how,' he said. 'Now we know that depolarizations occur abundantly and are important to patient outcomes. This is the question we set out to answer when we started COSBID.'
He added: 'Our ability to monitor and understand what happens in the brain after a severe injury hasn't advanced significantly in decades. The brain is like a black box, but the process of spreading depolarizations now gives us a window into that box. Being able to treat patients based on specific cellular brain events we can measure and monitor would be a great advance.'
Dr. Hartings's Cincinnati co-investigator was Lori Shutter, MD, director of neurocritical care at the UC Neuroscience Institute.
When a brain injury occurs, nerve cells in the brain, which act like batteries by storing electrical and chemical energy , malfunction and effectively short-circuit. Because all nerve cells in the brain are connected, this depolarization causes all the neighboring cells to short-circuit as well; this subsequent leakage of precious electrical charge moves like a tsunami through the brain, with the potential to cause additional permanent tissue damage.
To measure the depolarizations, researchers placed a linear strip of electrodes on the surface of the brain, near the injured area, during neurosurgery. Only patients who required brain surgery to treat their injuries were enrolled in the study. King's College Hospital is a Major Trauma Centre for London, and regularly treats patients who are suitable candidates for the trial.
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