login
Become a member
Quick Registration
Full Registration Benefits -
Free Homepages for Doctors
Free Homepages for Hospitals
Free Homepages for Medical Conference
Free Homepages for NGO's
Personal Health Record Creation
Access to all Medical Slides
Access to all Jobs & Products Sale
Using Metoprolol During Surgery Linked to High Death and Stroke Risk
The findings are based on POISE, the world's largest randomised trial addressing perioperative cardiac complications.
The trial evaluated the effects of a beta-blocker versus placebo given to patients around the time of surgery.
"POISE demonstrates that a beta-blocker given around the time of surgery decreases a patient's risk of a heart attack but increases their risk of a major stroke and death," The Lancet quoted Dr. P.J. Devereaux, POISE co-principle investigator, McMaster University, Hamilton, Canada, as saying.
Surgery boosts patients' catecholamines, or stress hormones, which increase the heart's requirement for oxygen.
And stress on the heart can cause serious events such as a heart attack.
Since beta-blockers reduce the effects of increased catecholamines some doctors thought that they might prevent serious heart complications around the time of surgery.
"Initial small trials suggested beta-blockers were beneficial around the time of surgery but more recent moderate sized trials did not show any benefit. We undertook POISE to provide a clearer understanding of the effects of a beta-blocker around the time of surgery," Dr. Homer Yang, POISE co-principal investigator, University of Ottawa, Ottawa, Canada.
Dr. Salim Yusuf, POISE steering committee chair, McMaster University, Hamilton, Canada, said: "A major accomplishment of POISE was that anesthesiologists, cardiologists, internists, and surgeons at 190 centres in 23 countries came together and randomised 8,351 patients - more than 4 times as many patients than all the previous perioperative beta-blocker trials combined. Such efforts are rare, but essential in order to make progress in the management of these patients."
|
|
|
More News on: Bells Palsy, Diet Lifestyle and Heart Disease, Mitral Valve Stenosis And Mitral Valve Replacement, Congenital Heart Disease, Stress and the Gender Divide, Death Facts, Stroke Facts, Stroke, Geriatry-Related Diseases, Hyperventilation
 Comment & Contribute
|
Medwonders Health Network
- Health News Index
|
|
- News Quick Links
 |
Stroke
Complete Medindia Resources
|
| News Categories: |
| » | Michelle Obama: Name of Olive Tree in Italy |
| » | Beyonce: Most Beautiful Women in the World |
| » | Robin Gibb Recovers from Coma Wakes Up to Cancer |
| » | Botox and Vitamin Jabs Maintain Simon Cowell’s Young Looks |
| » | Victoria Beckham Hoping to Launch Lifestyle Website |
| More Celebrity News | |
|
