A recent study shows that the use of probiotic is superior to antibiotics for treating recurrent urinary tract
infections in women.
Ann E. Stapleton.and her colleagues conducted a randomized double-blind phase 2
study for assessing the impact of pro-biotic in preventing and controlling
occurrences of urinary tract infection.
The intravaginal application of probiotic consisting of Lactobacillus
crispatus CTV-05 or
Lactin-V from Osel
Inc have proved
to be beneficial in limiting the recurrence of urinary tract infection (UTI) by almost fifty percent in UTI- susceptible women.
Significantly large studies are needed to
necessitate the replacement of long prevalent antimicrobial preventive methods
by vaginal Lactobacillus in prone females.
Ann Stapleton, MD, in the Washington University,
Seattle, observed that the females with
UTI occurring tendencies have a deranged vaginal flora that leads to decrease in
Lactobacilli.
It was noted in phase 1 of the study of Lactin-V that administration of the probiotic as
vaginal suppository in females with recurrent UTI history resulted in minimum
side effects. 100 premenopausal females with prior UTI history (median
age 21 years) in the phase 2 study, were given antimicrobial drugs and later on
randomly picked to either use placebo
vaginal suppository or ( Lactin-V . The treatment was given once a day for 5 days. Follow up
was done weekly for 10 weeks.
Dr.
Stapletons study revealed that recurrent UTI was seen to occur in only 7 (15%) of 48 ladies receiving Lactin-V
while with placebo the recurrent
UTI was seen in 13 (27%) females.
Studies established the relative risk [RR], .5; 95% confidence interval
[CI], .2 - 1.2).