Urinary Tract Infection Prevention by Use of Probiotic

by Dr. Seema Nigar Alvi on  April 26, 2011 at 2:37 PM General Health News
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A recent study shows that the use of probiotic is superior to antibiotics  for treating recurrent urinary tract infections in women.

Ann E. Stapleton.and her colleagues  conducted a randomized double-blind phase 2 study for assessing the impact of pro-biotic in preventing and controlling occurrences of urinary tract infection.

The intravaginal application of probiotic consisting of Lactobacillus crispatus CTV-05  or  Lactin-V  from Osel Inc have proved to be beneficial in limiting the recurrence of urinary tract infection  (UTI) by almost fifty percent  in UTI- susceptible  women.

Significantly large studies are needed to necessitate the replacement of long prevalent antimicrobial preventive methods by vaginal Lactobacillus in prone females.

Ann Stapleton, MD, in the Washington University, Seattle,  observed that the females with UTI occurring tendencies have a deranged vaginal flora that leads to  decrease in  Lactobacilli.

It was noted in phase 1 of the study of Lactin-V that administration of the probiotic as vaginal suppository in females with recurrent UTI history resulted in minimum side effects. 100 premenopausal females with prior UTI history (median age 21 years) in the phase 2 study, were given antimicrobial drugs and later on randomly picked to either use  placebo vaginal suppository or ( Lactin-V . The treatment was given once a day for 5 days. Follow up was done weekly for 10 weeks.

Dr. Stapleton’s study revealed that recurrent UTI was seen to occur in only  7 (15%) of 48 ladies receiving  Lactin-V  while with placebo the recurrent UTI was seen in 13 (27%) females.  Studies established the relative risk [RR], .5; 95% confidence interval [CI], .2 - 1.2).

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