Fat deposits on chest and back increase the risk of insulin resistance which leads to type2 diabetes. It is for the first time that such an association is made between the two and it was seen to be strong both in HIV infected subjects and HIV negative control subjects in the Study of Fat Redistribution and Metabolic Change in HIV Infection (FRAM). The researchers from the San Francisco VA Medical Center (SFVAMC) conducted a national long-term longitudinal study of HIV infected people taking modern antiretroviral therapy and HIV negative controls.
The presence of visceral fat, which is located between and around the internal organs, was also associated with an increased risk of insulin resistance in both populations. The researchers found that each type of fat contributes independently to insulin resistance whether or not the other type is present.
The study appears in online Publish Ahead of Print section (http://www.jaids.com/pt/re/jaids/paptoc.htm) of the Journal of Acquired Immune Deficiency Syndromes.
We knew about the insulin resistance risk associated with visceral fat, which has been shown in previous studies, but no one had ever looked at the contribution of upper trunk fat, says lead author and FRAM principal investigator Carl Grunfeld, MD, PhD, chief of the metabolism and endocrine sections at SFVAMC. Strikingly, there was very little difference between HIV infected people and controls. If you have fat up top, its bad for you.