Ewing sarcoma (EWS) is a bone tumor of unknown cellular origin that affects children and young adults. The protein CD99 is highly expressed in most cases of EWS, but its function in the disease is unknown. Now, Katia Scotlandi and colleagues, at SSN Emilia Romagna Istituto Ortopedico Rizzoli IRCCS, Bologna, Italy, have identified a crucial role for CD99 in the development of EWS and suggest that targeting CD99 or its downstream molecular pathway may be a new therapeutic approach for EWS.
In the study, decreasing CD99 expression in human EWS cell lines reduced their ability to form tumors xenografted into mice. In vitro, it increased expression of H-neurofilament, a marker of neuronal differentiation. Consistent with this, an inverse correlation between CD99 expression and H-neurofilament expression, neural differentiation, and oncogenic transformation was observed in patient-derived EWS cells. The authors therefore conclude that CD99 prevents neural differentiation and suggest that blocking it might provide a new approach to treating EWS.
Caucasians More At Risk Of Developing Ewing's Sarcoma Than Other Races
The largest analysis of its kind has found that Caucasians are much more likely than people in other racial/ethnic groups to develop a rare bone and soft tissue cancer called Ewing's sarcoma.
The largest analysis of its kind has found that Caucasians are much more likely than people in other racial/ethnic groups to develop a rare bone and soft tissue cancer called Ewing's sarcoma.
Source-Eurekalert
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Rhabdomyosarcoma Unplugged
Rhabdomyosarcoma (RMS) is a severe muscle cancer commonly affecting children. Embryonal rhabdomyosarcoma (ERMS) and alveolar rhabdomyosarcoma are the most common forms of RMS.
Rhabdomyosarcoma (RMS) is a severe muscle cancer commonly affecting children. Embryonal rhabdomyosarcoma (ERMS) and alveolar rhabdomyosarcoma are the most common forms of RMS.
Molecule Involved in Disrupting Ewing's Sarcoma Oncogene Identified
American scientists have identified a small molecule that may be helpful in inactivating a gene that causes Ewing's sarcoma, a rare cancer found in children and young adults.
American scientists have identified a small molecule that may be helpful in inactivating a gene that causes Ewing's sarcoma, a rare cancer found in children and young adults.
Progression of Sarcoma Slowed by Reishi Mushroom and Green Tea Extracts
A team of researchers has suggested that combining the active ingredients in Reishi mushroom (Ganoderma lucidum; Lingzhi) and green tea creates synergetic effects that inhibit the
A team of researchers has suggested that combining the active ingredients in Reishi mushroom (Ganoderma lucidum; Lingzhi) and green tea creates synergetic effects that inhibit the
