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'Trojan Horse' Can Kill Cancer Cells: Researchers

by Sreeraman on June 30, 2009 at 2:55 PM Research News

Australian researchers are set to begin human trials of a tiny nano-cell that acts as a "Trojan horse" against cancer cells, a breakthrough they say may curb the need for debilitating chemotherapy.

'Trojan Horse' Can Kill Cancer Cells: Researchers

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The technology could eventually allow cancer sufferers to receive treatment as outpatients, rather than being hospitalized for lengthy bouts of chemotherapy, according to the researchers.

Himanshu Brahmbhatt from Sydney-based biotechnology company EnGeneIC said the research, outlined in the journal Nature Biotechnology -- had the potential to reduce the side-effects of cancer treatment and make it cheaper.

Brahmbhatt said the technology allowed medics to target cancer cells without damaging healthy tissue, a major problem with existing chemotherapy treatments.

"Essentially you need to get the drug directly inside the cancer cell and not slug the body," he told the Australian Broadcasting Corporation.

While researchers have been working on using nano-cells against cancer for at least five years, Brahmbhatt said the latest version had proved 100 percent effective treating cancers in mice which were resistant to conventional chemotherapy.

The cells were loaded with anti-cancer medications and deployed in "waves" to combat cancers, he said.

"The first wave of Trojan horses goes in there and disables the resistance mechanisms inside the cancer cell," he said.

"Interestingly, these cancer cells are totally receptive to repeated waves of these Trojan horses.

"We can send in these nano-cells again and again and each time we can load them up with different types of armaments against cancer."

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