login
Become a member
Quick Registration
Full Registration Benefits -
Free Homepages for Doctors
Free Homepages for Hospitals
Free Homepages for Medical Conference
Free Homepages for NGO's
Personal Health Record Creation
Access to all Medical Slides
Access to all Jobs & Products Sale
Treatment-resistant Colon Cancer May be Fought With a Novel Approach
Lead researcher Satya Narayan has found that addition of a small molecule to the cancer drug disrupts repair mechanisms in tumour cells.
"This is very important because aside from aggressive surgery with possibly chemotherapy, there are no specific treatments for colon cancer," said Narayan, a professor of anatomy and cell biology at the College of Medicine and a member of the UF Shands Cancer Centre.
"The recurrence rate for this type of cancer after surgery is very high, about 30 to 50 percent, and there is an urgent need to develop new approaches to manage this deadly disease," Narayan added.
The research team evaluated more than 140,000 small molecules, when they finally arrived at a tiny molecule that precisely blocks the ability of cancer cells to recognize and repair the DNA damage inflicted by Temozolomide, or TMZ.
"Our idea was if you induce DNA damage (with TMZ), and at the same time block cell repair, you can synergize toxic effects to the cancer cells," Narayan said.
"We hope that with this combination treatment we can reduce the tumours drastically and expand the lifetime of patients much longer than is currently possible," Narayan added.
By combining TMZ with the small molecule, researchers were able to disable the colon cancer's ability to manufacture repair enzymes.
|
|
|
More News on: Cancer and Homeopathy, Colo-rectal cancer - Management, Colorectal Cancer, Cancer Facts, Cancer, Tattoos A Body Art, Colon, Crohns Disease, Amyotrophic Lateral Sclerosis (ALS), Olive Oil and Its Benefits
 Comment & Contribute
|
Medwonders Health Network
- Health News Index
 | Quiz on Cancer Looking for information on cancer? Go through medindia's Cancer quiz. 
|
- News Quick Links
 |
Colon
Complete Medindia Resources
|
| News Categories: |
| » | Research: Bright Colored Chips can Cut Consumption by Half |
| » | Olympic Athlete's Body Via the 80-10-10 Raw Vegan Diet |
| » | Importance of Canned Foods To Help Tackle IOM Weight Of The Nation Recommendations, Highlights Study |
| » | US Rules Pomegranate Juice Claims Deceptive |
| » | Reducing Entrée Size Could Increase Fruit and Vegetable Intake in Children |
| More Diet News | |
|
