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Treatment of Neuroblastoma in Near Future?
April 15, 2008 at 4:12 PM
Cancer News
In the study, researchers found that inhibiting the production of ornithine decarboxylase ODC1 - a gene driven by the MYCN oncogene that is a powerful predictor of death from this disease - delayed or prevented the development of neuroblastoma in a clinically relevant animal model.
This suggested that suppressing ODC1 could be target for treating this cancer.
"This disease, particularly in patients whose tumors carry multiple copies of the MYCN oncogene, has a particularly poor prognosis and new therapies are urgently needed," said Michelle Haber, Ph.D., professor and executive director of Children's Cancer Institute Australia for Medical Research in Sydney, Australia.
"Our findings suggest that MYCN-driven over-expression of ODC1 in this disease, or genetic variations associated with increased expression of the gene, contribute to the aggressive biology of this tumor, and that inhibition of this gene may lead to an important new therapeutic avenue for this disease," Haber added.
For the study, researchers examined 209 patients with untreated neuroblastoma.
Researchers confirmed that older age, advanced stage and MYCN amplification were all associated with highly aggressive disease and poor clinical outcomes.
In a subsequent animal study, researchers examined whether inhibiting ODC1 activity with difluoromethylornithine (DFMO), a proven ODC1 inhibitor, would improve treatment of neuroblastoma, when used in combination with conventional chemotherapeutic drugs.
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