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Treatment for Rheumatoid Arthritis in Bone Marrow Cancer Drug
The study conducted by Greek researchers has suggested that the biologic drug bortezomib (Velcade), a proteasome inhibitor used to treat multiple myeloma (bone marrow cancer), may be useful for RA as well.
In the study, bortezomib displayed favorable effects in an animal model of inflammatory arthritis that mimics RA, in reducing disease severity and inflammation, and promoting bone healing.
RA is a chronic, systemic, autoimmune disease characterized by inflammation and joint destruction.
"The definitive role of biologic agents in treating this difficult-to-cure population has yet to be defined in prospective trials comparing the available therapeutic options," explained study leader Evangelia Yannaki.
"Given the lack of options for poor responders and the increased risk of infections and malignancies with available biologic agents for RA, there is a great need for novel therapies that are safe and effective," he added.
The research team explored bortezomib as an optimal treatment for RA because the drug targets multiple pathways.
In analysis, researchers noted that joints in animals treated with the drug displayed limited damage and inflammation, and an obvious bone healing effect was observed.
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More News on: Bone Marrow Biopsy, Drug Toxicity, Osteoarthritis, Leucopenia, Rheumatoid Arthritis, Infantile Cortical Hyperostosis, Cancer and Homeopathy, Oligoarthritis, Physiotherapy Utilities, Spondylolisthesis
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