Advertisement

Most Popular on Medindia

P
M

Treating Anemia Would Make Kidney Transplants More Successful

by VR Sreeraman on  December 23, 2011 at 7:13 PM Organ Donation News   - G J E 4
Researchers have found that aggressively treating treating anemia, a red blood cell deficiency, may help save kidney thereby saving the lives of many transplant recipients.
 Treating Anemia Would Make Kidney Transplants More Successful

Anemia commonly arises in patients with kidney disease because the kidneys secrete most of the hormone erythropoietin that stimulates red blood cell production. Anemia is also a common complication of kidney transplantation, with a prevalence of 25% to 40% after the first year.

Gabriel Choukroun, MD, PhD (CHU Amiens in France) and his colleagues initiated the Correction of Anemia and PRogression of Renal Insufficiency in Transplant patients (CAPRIT) study to see if the drug epoetin beta (a synthetic form of erythropoietin) could help preserve kidney function in kidney transplant recipients with anemia. Specifically, the investigators tested whether completely correcting anemia (by normalizing levels of hemoglobin, a blood component that carries oxygen) is better than partially correcting anemia.

During the study, 63 kidney transplant recipients took epoetin beta so that their hemoglobin levels remained in the normal range of 13.0 to 15.0 g/dL, while 62 patients took epoetin beta so that their hemoglobin levels hovered at a lower concentration of 10.5 to 11.5 g/dL.

Among the major findings after patients were treated for two years:
  • 4.8% of patients with completely corrected anemia developed kidney failure, compared with 21% of patients with partially corrected anemia.
  • 94.6% of transplanted kidneys in patients with completely corrected anemia were functional, compared with 80% in patients with partially corrected anemia.
  • Patients with completely corrected anemia experienced a significant improvement in quality of life at six and 12 months after starting therapy.

"This study shows that correction of anemia in kidney transplant recipients with anemia slows the progression of kidney failure and improves survival of transplanted kidneys," said Dr. Choukroun. Additional studies are needed to determine whether this also prolongs patients' lives.

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

Ask an Expert

C
If you have a question about health related issues, you can now post it in our Ask An Expert section on our community website Medwonders.com and get answers from our panel of experts.
X

Ask an Expert

Ask an Expert+
s
Possible Cure For Leukemia Found in Fish Oil
 Possible Cure For Leukemia Found in Fish Oil
S  MRI Scan A Better Option For Diagnosing Heart Disease
MRI Scan A Better Option For Diagnosing Heart Dis...