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Tracking Yeast Mutations may Improve Understanding of Role of Genes in Human Diseases: Study
Scientists from the University of New Hampshire, Indiana University, Harvard University, and the University of Utah have found that yeast mutates in a distinctly different pattern than other model organisms.
"In biology, the mutation is an absolutely fundamental process, essential to evolution but also the source of all genetic disease," says Kelley Thomas, associate professor of biochemistry and director of the Hubbard Center for Genome Studies at the University of New Hampshire.
"Despite its importance, we still don't know much about the basic processes of mutation," he adds.
Reporting their findings in Proceedings of the National Academy of Science (PNAS) Online Early Edition this week, the researchers have pointed out that cancers are caused by mutations, as are inherited diseases like Huntington's disease and fragile X syndrome, the most common inherited form of mental retardation.
"If we know more about the patterns of mutation, we'd be able to better understand the origins of these diseases - and maybe prevent them," says Thomas.
The researcher team set out to determine the baseline rate and spectrum of mutation in yeast, and found that, like the previously studied mutations in the nematode C. elegans, the yeast Saccharomyces cerevisiae had a very high rate of mutation from generation to generation.
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