Medindia

X

Toxic Drugs may Not Benefit Kidney Transplant Patients

by Kathy Jones on  September 24, 2011 at 5:50 PM Organ Donation News   - G J E 4
It is well-known that patients who receive kidney transplants must take lifelong medications. While these medications prevent organ rejection, they can also compromise other aspects of health.
Toxic Drugs may Not Benefit Kidney Transplant Patients
Toxic Drugs may Not Benefit Kidney Transplant Patients
Advertisement

Immunosuppresive drugs called calcineurin inhibitors protect transplanted organs from being rejected, but they can be toxic to the kidneys over the long term and can make patients susceptible to infection, cancer, and other threats.

Advertisement
A new analysis has found that transplant patients can safely minimize or avoid using calcineurin inhibitors. The study, conducted by Richard Borrows, MD and his colleagues at the Renal Institute of Birmingham, in England, appears in an upcoming issue of the Journal of the American Society Nephrology (JASN), a publication of the American Society of Nephrology.

The investigators examined dozens of studies conducted between1966 and 2010 that compared different treatments following kidney transplantation. When they weighed the risks and benefits of avoiding or reducing calcineurin inhibitors immediately after kidney transplantation, the researchers found that the strategy improves kidney function without causing rejection in the short-to-medium period after transplantation. In many cases, patients took newer immunosuppressive drugs that are less toxic to the kidneys.

Approximately 94% of kidney transplant recipients take calcineurin inhibitors after being discharged from the hospital. "This study suggests that after 30 years of using calcineurin inhibitors, it may now be possible to undertake safe and effective transplantation without these drugs, at least in some groups of patients," said Dr. Borrows.



Source: Eurekalert
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

Advertisement
View All