Topiramate may Be Useful in Treating Alcohol Addiction

by Rajshri on  June 11, 2008 at 3:11 PM Drug News
RSS Email Print This Page Comment
Font : A-A+

 Topiramate may Be Useful in Treating Alcohol Addiction
Experts at the University of Virginia Health System have revealed that topiramate is an effective therapeutic agent that can curb heavy drinking. Furthermore the researcher say it can be used to treat alcohol dependence as well.

The researchers say that their findings could pave the way for new treatments for alcoholism.

"What we've found is that topiramate treats the alcohol addiction, not just the 'symptom' of drinking," says lead author Professor Bankole Johnson, D.Sc., M.D., Ph.D., M.Phil., FRCPsych., chairman of the UVa Department of Psychiatry and Neurobehavioral Sciences.

The results of the 14-week trial, which involved 371 male and female diagnosed alcoholics, indicates that topiramate was more efficacious than placebo in decreasing body mass index (BMI) and all liver enzymes including the log plasma a-glutamyl-transferase ratio, which is the objective marker of heavy drinking.

Researchers found that Topiramate was considerably more efficacious than placebo in reducing both systolic and diastolic blood pressure by a mean difference of 9.70 mm Hg and 6.74 mm Hg, respectively.

Topiramate also significantly lowered plasma cholesterol levels by an average of 16.4 mg/dL compared with a reduction of 5.7 mg/dL with placebo.

These combined effects suggested that topiramate might decrease the risk of heart disease in alcohol dependent individuals.

"Many alcoholics have hypertension, and some receive anti-hypertensive medication, which can complicate their treatment for alcoholism. Because topiramate can reduce drinking substantially and decrease blood pressure significantly, this allows one medication to be given instead of several," Johnson said.

The study showed that by decreasing liver enzymes and cholesterol levels, topiramate also might reduce the risk of fatty liver disease, which leads to cirrhosis - a common consequence to end-stage liver disease leading to death in alcoholics.

Also, topiramate significantly contributed to a decline in obsessive thoughts and compulsions about using alcohol.

Topiramate also had a greater quality of life improvement than placebo in general activities, leisure activities and household duties, as well as a reduction in sleep disturbances.

Although, the Food and Drug Administration has approved topiramate for seizures and migraine headaches, it is not currently approved for treating alcohol dependence.

The study is published in the June 9 issue of the Archives of Internal Medicine.

Source: ANI
RAS/L

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
* Your comment can be maximum of 2500 characters
Notify me when reply is posted
I agree to the terms and conditions
guest Wednesday, August 6, 2008

Few treatment centers offer holistic program to address the physical, mental, emotional, interpersonal and spiritual areas for recovery. They teach the clients to lead a disciplined and healthy life style through different programs

Related Links

More News on:

Alcoholic Liver Disease Iodine Deficiency Disorder Alcohol abuse Cannabis Drug Abuse Alcohol and Driving Bubbles and Brews - Alcohol Facts Pancreatitis Alcohol Addiction and Women Drug Detox 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

News Category

News Archive