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Tobacco Use in Patients With HPV-positive Head and Neck Cancer Worsens Outcome
High-risk HPVs are the same viruses that are associated with cancers of the uterine cervix.
The research suggests that current or former tobacco users may need a more aggressive treatment regimen than patients who have never used tobacco.
In the new study, boffins found that current tobacco users with HPV-positive tumors were five times more likely to have their cancer recur. Even former smokers had an increased risk of recurrence.
"Because the effect of HPV is so strong in giving a very good prognostic picture, we were surprised to find that smoking remained a huge issue, and it actually affected the outcome in patients who smoked," says senior study author Thomas Carey, Ph.D., professor of otolaryngology and pharmacology, and co-director of the Head and Neck Oncology Program at the U-M Comprehensive Cancer Center.
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