Tiny Sacs Released By Cancer Cells May Offer Effective Cure for Brain Tumour

by Sreeraman on  November 18, 2008 at 2:47 PM Research News
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Massachusetts General Hospital (MGH) researchers say that brain tumour cells release tiny sacs called microvesicles, which contain information that may prove helpful in developing an effective treatment for the disease.

The researchers claim that they have found tumour-associated RNA and proteins in membrane microvesicles called exosomes in blood samples from glioblastoma patients.

Upon deeply analysing exosome contents, say the researchers, they could identify factors that could facilitate a tumour's growth through delivery of genetic information or proteins, or signify its vulnerability to particular medications.

"Glioblastomas release exosomes in sufficient quantities to pass the blood-brain barrier. We were able to isolate them, analyze the RNA transcripts and show how they might be used as biomarkers to guide targeted therapy and monitor treatment response," Nature Cell Biology quoted Dr. Johan Skog, who works in the laboratory of Dr. Xandra Breakefield at the MGH Neuroscience Center, as saying.

"Exosomes also may someday be used to deliver therapeutic molecules to the site of a tumour," added the study's lead author.

The research team claim that they are the first to carefully analyse the contents of exosomes shed from glioblastoma cells, and characterize their contents.

During the study, the researchers first analysed tumour cells from three glioblastomas, and verified that the cells released exosomes containing RNA and protein molecules.

The team observed that some messenger RNAs related to activities like cell proliferation and migration, angiogenesis, and immune response were highly abundant in the exosomes.

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