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Thymus Stimulation Therapies Restore T-Cell Production-To Aid HIV-infected Adults
The thymus gland, which produces T-cells, gradually becomes mostly inactive during adulthood, a process called involution. This makes it difficult for HIV-infected adults to make new T-cells.
The researchers believe that therapies that stimulate the thymus to produce new T-cells may be helpful in restoring the embattled immune system to HIV-infected patients.
For a long time now, scientists have believed that the thymus cannot be reactivated in humans. However, the new study shows that the thymus can be stimulated to produce more T-cells.
Writing about their findings in the Journal of Clinical Investigation, the research team claimed that they were the first to show that pharmacologic therapies could be used to enhance human thymic function.
“These results represent new proof-of-principle findings that thymic involution can be reversed in humans” said Dr. Laura Napolitano, lead author of the study, an Assistant Investigator at Gladstone and Assistant Professor of Medicine at UCSF.
“Improved T-cell production may be helpful for some medical conditions such as HIV disease or bone marrow transplantation. These findings contribute new information to our understanding of T-cell production and are also an important step to determine whether immune therapies might someday benefit patients who need more T-cells,” she added.
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