Throat Cells ‘killed’ by Diesel Exhaust: Study

by VR Sreeraman on  September 13, 2007 at 2:34 PM Research News   - G J E 4
Throat Cells ‘killed’ by Diesel Exhaust:  Study
Researchers at School of Life and Environmental Sciences, Deakin University headed by Associate Professor Leigh Ackland compared the effects of diesel exhaust and biodiesel exhaust on human airway cells and concluded that diesel exhaust is far more injurious to health than the plant-based biodiesel.

They found that diesel exhaust damaged and killed the cells, while biodiesel exhaust had little effect. "Australia's escalating need for fuel is posing a major health problem," Associate Professor Ackland said.

"The fumes from burning fuels, including diesel, contributes to pollution and can cause heart disease, bronchitis and asthma. Efforts are underway to replace petrol and diesel with cleaner biofuels, such as biodiesel, but there is considerable resistance to this. This study provides clear evidence that diesel exhaust is more harmful to our health than biodiesel exhaust," she added.

Since doing a real-time study on real human airway was impossible, the researchers conducted their research on human airway cells grown in a culture.

They exposed the cells to the particulate matter emitted in diesel and biodiesel exhaust fumes. "Particulate matter is the burnt material, including carbon particles, emitted into the air. This particulate matter is part of biodiesel and diesel fumes but the particles produced from biodiesel were much less damaging to the cells than particles produced from diesel," Ackland said.

"Our research found that the particulate matter from diesel exhaust stimulated a 'death pathway' response that the body uses to dispose of damaged cells. This response caused the airway cells to fuse together and die. We saw hardly any cell death after treatment with biodiesel particulates," she added.

Ackland said that the new findings strengthened the belief that it was time to replace petrol and diesel with cleaner biofuels. "It is clear that breathing in diesel fumes is going to have a far more detrimental effect on our health than biodiesel. Given the level of cell death we have found, diesel exhaust could be the cause of respiratory disorders such as asthma and could even be implicated in cancer," she said.

The study has been published in the journal Immunology and Cell Biology.

Source: ANI

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