Medindia

X

Therapeutic Targets for Neuroblastoma Identified

by Savitha C Muppala on  February 16, 2010 at 11:27 PM Cancer News   - G J E 4
 Therapeutic Targets for  Neuroblastoma Identified
Scientists have identified potential therapeutic targets for the treatment of neuroblastoma, the most frequent solid tumour in young children.
Advertisement

By studying human neuroblastoma cells in vitro and after xenotransplantation into mice and chicks, a team of researchers, led by Patrick Mehlen, at Universite de Lyon, France, has identified the protein NT-3 and the cell-surface molecule to which it binds (TrkC).

Advertisement
In the study, NT-3 was found to be expressed at increased levels in aggressive human neuroblastomas and to block the ability of TrkC to induce tumour cell death by a process known as apoptosis.

In vitro analysis of human neuroblastoma cell lines indicated that both decreasing NT-3 expression and culturing in the presence of an antibody that blocked NT-3 binding to TrkC triggered the cells to undergo apoptosis.

More importantly, blocking the NT-3/TrkC interaction inhibited tumour growth and metastasis in both a chick and a mouse xenograft model of neuroblastoma.

The authors therefore suggest that disrupting the NT-3/TrkC interaction might provide a new approach to treating neuroblastoma, a form of cancer for which treatment options are urrently limited. (ANI)

Source: ANI
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

Advertisement
View All