The Search for the Human Fountain Of Youth Seems to Have Yielded Some Result

by Savitha C Muppala on  September 18, 2010 at 11:39 PM Research News   - G J E 4
A new research from Concordia University has brought us closer to realizing our dream for a longer life.

The new study is the first to identify the role of a bile acid, called lithocholic acid (LCA), in extending the lifespan of normally aging yeast.
The Search for the Human Fountain Of Youth Seems to Have Yielded Some Result
The Search for the Human Fountain Of Youth Seems to Have Yielded Some Result

The findings may have significant implications for human longevity and health, as yeast share some common elements with people.

"Although we found that LCA greatly extends yeast longevity, yeast do not synthesize this or any other bile acid found in mammals," says senior author Vladimir Titorenko, Concordia University Research Chair in Genomics, Cell Biology and Aging and a professor in the Department of Biology.

"It may be that yeast have evolved to sense bile acids as mildly toxic molecules and respond by undergoing life-extending changes. It is conceivable that the life-extending potential of LCA may be relevant to humans as well."

Titorenko and colleagues screened more than 19 000 small molecules to test their ability to extend yeast-lifespan. Under both normal and stressed conditions, LCA had a major impact.

"Our findings imply that LCA extends longevity by targeting two different mechanisms," says first author Alexander Goldberg, a Concordia doctoral student.

"The first takes place regardless of the number of calories and involves the day-to-day or housekeeping proteins. The second system occurs during calorie-restriction and involves stressor proteins. Regardless of their triggers both of these mechanisms work to suppress the pro-aging process," he continues.

Titorenko says: "Although we have an overall idea how LCA works to extend longevity in yeast, we still need to determine if this is the case for other species. We do know from previous studies, however, that bile acids are beneficial to health and longevity. For example, they have shown to accumulate in the serum of long living mice and play a role in improving rodent liver and pancreatic function."

"This leads us to believe that bile acids have potential as pharmaceutical agents for the treatment of diabetes, obesity and various metabolic disorders, all of which are age-related. They may indeed offer hope for a healthy aging life," Titorenko adds.

The study has been published in the journal Aging.

Source: ANI

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

View All