Researchers at Einstein have found that potent immune system cells that usually defend against cancer can actually promote it.
The research team from Albert Einstein College of Medicine of Yeshiva University analysed the movement of breast cancer cells in mice to show that a distinct population of macrophages, the immune system cells, can promote cancer metastasis.
How Immune Cells Promote Tumor Growth In The Brain?
Gliomas are among the most common and most malignant brain tumors. These tumors infiltrate normal brain tissue and grow very rapidly. So, surgery can never completely remove the tumor.
Gliomas are among the most common and most malignant brain tumors. These tumors infiltrate normal brain tissue and grow very rapidly. So, surgery can never completely remove the tumor.
In three different ways, the scientists showed that metastatic tumour growth is inhibited if these unusual macrophages are killed.
They also showed that even after breast cancer cells have lodged in the animals' lungs and started aggressive growth, erasing the special macrophages dramatically slowed growth of the metastasized tumours.
Immune Cell Function Suppressed by Leading Pathogen in Newborns
Group B Streptococcus (GBS) is able to shut down immune cell function in order to promote its own survival, say researchers
Group B Streptococcus (GBS) is able to shut down immune cell function in order to promote its own survival, say researchers
Based on this new work, he added, "macrophages themselves, or their unique signalling pathways, represent new therapeutic targets that may be efficacious in reducing cancer mortality."
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Biochemical Signals That Help Immune Cells Remember How to Fight Infection Identified
Two biochemical signals that play unique roles in promoting the development of a group of immune cells that have total recall have been identified
Two biochemical signals that play unique roles in promoting the development of a group of immune cells that have total recall have been identified
Source-ANI
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