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The Genetic Connection Between Misery and Death
The new study has also discovered a specific genetic variation in some people that apparently disconnects that link, rendering them more biologically tough to face adversity.
Steven Cole, a member of the UCLA Cousins Center for Psychoneuroimmunology and an associate professor of medicine in the division of hematology-oncology, and his team have developed a unique strategy for finding and confirming gene-environment interactions to more efficiently investigate what he calls the "genetic haystack."
Cole and his team used an approach that blends computational, in vivo and epidemiological studies to look at specific groups of proteins known as transcription factors, which regulate gene activity and mediate environmental influences on gene expression by binding to specific DNA sequences. These sequences differ within the population and may have an effect on a gene's sensitivity to environmental activation.
Particularly, Cole analysed transcription factor binding sequences in a gene called IL6, a molecule that is known to cause inflammation in the body and that contributes to cardiovascular disease, neurodegeneration and some types of cancer.
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