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The Connection Between Thalidomide and Severe Birth Defects

by Savitha on  May 14, 2009 at 2:30 PM Drug News
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The Connection Between Thalidomide and Severe Birth Defects
The question troubling scientists for 50 years regarding the connection between thalidomide and birth defects, experienced by many pregnant women of the fifties , seems to have found an answer in the findings of Scot researchers.


Dr. Neil Vargesson, of Aberdeen University, accords the reason to a component of the drug that prevented the growth of new blood vessels, and subsequently caused limb defects in the developing embryo.

"We have put to rest a 50-year puzzle, in finally deducing how thalidomide triggers limb defects and why it appears to target limbs preferentially. This is an important discovery. Many models have been suggested as to how these defects were caused but now we know how it worked," the Scotsman quoted the lecturer in Developmental Biology as saying.

"This is the first paper to conclusively show that it is the anti-angiogenic property of the drug - that element that inhibits new blood vessel formation - that is to blame for the defects. The drug prevented early blood vessels going into the limb," Vargesson added.

But Martin Johnson, the director of the Thalidomide Trust cast a shadow of doubt on the claims, saying: "These findings are a puzzle to me. A number of people believe this mystery was solved ten years ago when the theory these people are following was comprehensively demolished."

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