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The Best Candidate Genes for Bipolar Disorder Identified
Reporting their work in the American Journal of Medical Genetics, the researchers revealed that they combined data from the latest large-scale international gene hunting studies for bipolar disorder with information from their own studies, which helped them identify the best candidate genes for the illness.
Dr. Alexander B. Niculescu III, an assistant professor of psychiatry and director of the laboratory of neurophenomics at the IU School of Medicine, said that his team mined the data from the genome-wide association studies and other study results on the levels of gene activity in human blood samples and in animal models.
He said that genes with the highest levels of prominence were determined to be the most active in contributing to the disorder.
He added that analysing the working of those genes, the team were able to create a comprehensive biological model of bipolar disorder.
"Based on our work, we now project that there will be hundreds of genes - possibly as much as 10 percent of the human genome - involved in this illness," said Dr. Niculescu.
"Not all genetic mutations will occur in every individual with bipolar disorder. Different individuals will have different combinations of genetic mutations. This genetic complexity is most likely what made past attempts to identify genes for the disorder through genetic-only studies so difficult and inconsistent."
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