Cancers generally spread to liver more than any other organ because of the immune system, US researchers have discovered. Hence targeting immune suppressive cells in patients with early cancer can have greater benefit, it is felt.
George Miller, from the Departments of Surgery and Cell Biology at the New York University School of Medicine. and colleagues conducted experiments in mice. In the experiments, the researchers used mice that spontaneously developed pancreatic cancer because of a mutation (Kras-mutation) in the progenitor cells of the pancreas, as well as mice with advanced colon cancers that spread to the abdomen. They then studied the expansion of immune suppressive cells in the liver from a very early stage in the cancer development to determine the immune phenotype, stimulus for recruitment, inhibitory effects and tumor-enabling function of these cells. Results suggest that combating immune suppressive cells in the liver early after cancer development may prevent the spread of cancer to this vital organ.
"Our work may open a new field of experimental therapeutics as combating the eventual development of liver metastases by targeting immune suppressive cells," said Miller.
"This study could represent one of those 'a-ha' moments in science where one idea or experiment opens up entirely new ways of approaching and understanding a problem," said Luis Montaner, Editor-in-Chief of the Journal of Leukocyte Biology
. "Physicians have known that the spread of cancer to the liver is far too common to occur by chance. Now we know that the immune system likely plays a role in facilitating this process. The next step, obviously, is to learn more so we can prevent it from happening."
The findings have been published in the Journal of Leukocyte Biology