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Sweet Tooth Turns Achilles' Heel For Salmonella - Makes a Vaccine Possible

by Tanya Thomas on  May 22, 2009 at 9:15 AM Research News   - G J E 4
 Sweet Tooth Turns Achilles' Heel For Salmonella - Makes a Vaccine Possible
It has been found that the food poisoning bug Salmonella, has an affiliation for glucose. This vulnerability, British scientists believe, could provide a new way to vaccinate against it.
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They say that the discovery of Salmonella's sweet tooth may also lead to vaccine strains to rotect against other disease-causing bacteria, including superbugs.

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"This is the first time that anyone has identified the nutrients that sustain Salmonella while it is nfecting a host's body," said Dr. Arthur Thompson from the Institute of Food Research.

During infection, Salmonella bacteria immune cells engulf them in a bid to destroy them.

But the bacteria instead have a tendency to multiply, for which they must acquire nutrients.

Focussing their study on glycolysis, the process by which sugars are broken down to create hemical energy, the researchers constructed Salmonella mutants unable to transport glucose nto the immune cells they occupy and unable to use glucose as food.

The mutant strains lost their ability to replicate within immune cells, which made them harmless

"Our experiments showed that glucose is the major sugar used by Salmonella during infection," aid Thompson.

The mutant strains still stimulate the immune system, and the scientists have filed patents on hem, which could be used to develop vaccines to protect people and animals against poisoning y fully virulent Salmonella.

Glycolysis occurs in most organisms, including other bacteria that occupy host cells, and thus isrupt how the bacteria metabolise glucose could be used to create vaccine strains for other athogenic bacteria, including superbugs.

The harmless strains could also be used as vaccine vectors.

Source: ANI
TAN
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