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Study on Bacterial Communication
Lead researcher Dr Pieter C. Dorrestein, assistant professor at UC San Diego's Skaggs School of Pharmacy and Pharmaceutical Sciences have developed novel tools that will enable scientists to understand how different cell populations of cells communicate.
Using a technology called natural product MALDI-TOF (Matrix Assisted Laser Desorption Ionization-Time of Flight) imaging mass spectrometry, the researchers could successfully translate the language of bacteria.
Microbial interactions, such as signaling, have generally been considered by scientists in terms of an individual, predominant chemical activity.
The new approach has enabled researchers to analyse the effects of multiple microbial signals in an interspecies interaction, revealing that chemical "conversations" between bacteria involve many signals that function simultaneously.
In order to communicate, bacteria secrete molecules that tell other microbes, in effect, "I am irritated, stop growing," "I need more nutrients" or "come closer, I can supply you with nutrients."
However, other molecules secreted by the microorganism may turn off the body's defense mechanisms.
In the new study, research team is currently mapping hundreds of such bacterial interactions.
"We want to begin to understand how those bacteria interact with our cells. This is a powerful tool that may ultimately aid in understanding these interactions," Nature quoted Dorrestein as saying.
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