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Study Shows How HIV Escapes Treatment

by Rajshri on March 08, 2010 at 7:11 PM AIDS/HIV News

A new study has found that the AIDS virus, HIV, can dodge treatment by staying dormant inside progenitor blood cells that develop into immune cells.

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These cellular reservoirs are resistant to the immune response of the host and the highly active antiretroviral therapy (HAART) administered to patients.

This means that the virus can attack white blood cells known as CD4+ T lymphocytes - which help the body to mount an immune response - after treatment.

"There are so many instances where patients stopped taking drugs and the virus rebounded. There is no way to get people off the drugs," Nature quoted lead author Kathleen Collins, a cellular biologist at the University of Michigan in Ann Arbor, as saying.

HAART can stop the spread of the virus by preventing the viral genome from integrating into new cells.

The combination of drugs used don't attack the cell that makes copies of the virus, but they can prevent the newly made virus from infecting more cells.

The researchers show that HIV can target haematopoietic progenitor cells (HPCs) from the bone marrow before they give rise to white blood cells.

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Study Shows How HIV Escapes Treatment

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