Study Sheds Light on The Making of Mucus in Common Lung Diseases

by Rajashri on  September 16, 2009 at 10:40 PM Respiratory Disease News
RSS Email Print This Page Comment
 Study Sheds Light on The Making of Mucus in Common Lung Diseases
Mucus is produced by cells known as goblet cells in the lungs. These cells are present in small numbers in the walls of the lungs and airways.

Many inflammatory stimuli, including allergens, cigarette smoke, and chronic infections, increase the number and activity of these goblet cells. This leads to mucus hyperproduction and subsequent airway obstruction and contributes to symptoms in several common lung diseases, including asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis (CF).

New research, by Jeffrey Whitsett and colleagues, at Cincinnati Children's Hospital Medical Center, has now determined that a molecular regulatory network controlled by the protein SPDEF governs allergen-induced goblet cell differentiation and mucus production in the lungs of mice. As evidence that the same network is active in goblet cells lining the airways of patients with chronic lung diseases, the authors suggest that SPDEF regulates a molecular network that controls the goblet cell differentiation and mucus hyperproduction associated with common lung disease, including asthma, COPD and CF.



Source: Eurekalert
RAS

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
* Your comment can be maximum of 2500 characters
Notify me when reply is posted
I agree to the terms and conditions

More News on:

Pneumoconiosis Silicosis 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

News Category

News Archive