Medindia

X

Study Sheds Light on Delayed Arrival of TB-fighting T Cells

by Kathy Jones on  June 15, 2010 at 8:17 PM Research News   - G J E 4
In mice, the outcome of tuberculosis infection is influenced by how quickly bacteria-fighting T cells can get to the lungs.
 Study Sheds Light on Delayed Arrival of TB-fighting T Cells
Study Sheds Light on Delayed Arrival of TB-fighting T Cells
Advertisement

According to a new study that will appear online on June 14th in the Journal of Experimental Medicine (www.jem.org), another group of T cells delays their arrival.

Advertisement
Previous research has shown that ridding the body of the hindering T cells—known as regulatory T cells—enhances the body's ability to fight off TB-causing bacteria. But exactly when and where regulatory T cells act was uncertain. The new study shows that these cells are activated at the same time and place as their bacteria-fighting "effector" cell counterparts. In response to infection, both populations expand in the lymph nodes that drain the lung. As a result, fewer effector T cells become activated and are dispatched to the lungs to fight the bug.

Others have shown that the most deadly strains of TB generate the most regulatory T cells, suggesting that this may be a tactic used by the bacteria to sidestep immune attack. Whether clinicians can devise a strategy to interfere with these troublesome cells in humans remains to be seen.



Source: Eurekalert
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

Advertisement
View All