Medindia

X

Study Says HIV Replication Process Could be Different Than Previously Thought

by Kathy Jones on  July 17, 2010 at 10:19 PM AIDS/HIV News   - G J E 4
A new study says that the process by which a retrovirus, like HIV, reproduces and assembles new viruses is different than previously thought.
 Study Says HIV  Replication  Process  Could be  Different  Than  Previously Thought
Study Says HIV Replication Process Could be Different Than Previously Thought
Advertisement

Researchers at Penn State College of Medicine studied a chicken virus called Rous sarcoma virus that causes cancer in chickens and is similar to HIV.

Advertisement
The start of the replication process is the production by the retrovirus of a protein called Gag.

Prior to this study, it was thought the building process happened outside the nucleus in the cyctoplasm- the material that fills the cell-and then Gag protein was sent to the plasma membrane- the outer boundary of the cell.

However, research revealed that Rous sarcoma virus takes a detour through the cell nucleus before going to the cell membrane.

The Gag protein binds to the viral RNA inside the nucleus, causing alteration in the structure of the protein.

"If we interfere with the first step, the virus will never be released from the cell. Cells are complex, so we use the key elements in a test tube to figure out how Gag and the RNA interact," said Leslie Parent, M.D., Ph.D., professor of infectious diseases, department of medicine.

Source: ANI
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

Advertisement
View All