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Study Says Chemo-Vandetanib Combo Effective for Lung Cancer Treatment
The research from The University of Texas MD Anderson Cancer Center has appeared in the Lancet Oncology.
The findings mark the first clinical benefit of a small molecule targeted agent and standard chemotherapy in combination for lung cancer.
Study's corresponding author Roy Herbst, professor and chief of the section of MD Anderson's Department of Thoracic/Head and Neck Medical Oncology, said: "This study shows that an oral tyrosine kinase inhibitor can be combined with chemotherapy safely and effectively to provide systematic benefit to patients with this life-threatening disease.
"Still, we need to build on this research and turn our focus toward better identifying molecular markers involved, with the ultimate goal of personalizing our patient's care."
The therapy is unique in that as it's a dual inhibitor and targets the epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor (VEGFR).
It is the first single agent in lung cancer to target both receptors, said Herbst, the study's international principal investigator.
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