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Study Reveals New Method to Delay Evolution of Drug Resistance in Malaria Parasite
David Smith, associate director of disease ecology at UF's Emerging Pathogens Institute and study's co-author, said that the new research would help scientists and policy makers in extending the longevity of current artemisinin-based malaria drugs combined with partner drugs.
Smith and colleagues created mathematical models assessing the strategic effectiveness and clinical outcomes of using one, two and three first-line drug therapies to treat malaria within a population over a 20-year period.
They found that using two or three drugs simultaneously reduced the total clinical cases and number of failed treatments, and slowed the rate at which drug-resistant genes spread within the parasites that cause malaria: Plasmodium falciparum, P. vivax, P. malariae and P. ovale.
"The models indicate that we can slow the evolution of resistance to current artemisinin-based therapies if nations use them in combination with two or more partner drugs," Smith said.
Smith said that artemisinin-combined therapies, or ACTs, are currently not widely implemented due to operational challenges and expense. However, he said that the study offers compelling evidence for global leaders to collaborate and overcome these issues.
"This is not to say that implementing multiple first-line therapies solves all of our malaria problems. Anti-malarial drug development needs to continue so that we have novel and highly effective anti-malarials that can be plugged into the recommended strategy of deploying multiple therapies," Boni said.
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More News on: Drug Toxicity, Malaria-water, Tapeworm Infections, Malaria, Mosquito Diseases, Trypanosomiasis, Signature Drug Toxicity, Drug Resistance - Antibiotic Resistance, Fever
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