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Study Points to the Benefit of Diabetes Drug in Fighting Lung Cancer in Mice

by Savitha.C.Muppala on September 02, 2010 at 4:37 PM Cancer News

A well-known diabetic drug has been found to significantly reduce tobacco-induced lung tumors in mice, a recent study has found.

Study Points to the Benefit of Diabetes Drug in Fighting Lung Cancer in Mice

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Researchers led by Philip Dennis, a senior investigator at the National Cancer Institute (NCI), gave the diabetes drug metformin to mice which had been exposed to a carcinogen derived from nicotine.

Mice treated orally with the diabetes drug had 40-50 percent fewer lung tumors than untreated mice, while those treated by injection had nearly three-quarters fewer tumors, the study published in Cancer Prevention Research said.

Based on the findings in mice, the researchers are considering holding clinical trials of metformin to determine if it could be used to prevent lung cancer in smokers.

"Although smoking cessation is the most important step for current smokers, over half of lung cancer cases are diagnosed in former smokers, raising the importance of identifying those at highest risk and identifying effective preventive treatments," Dennis said.

Earlier studies have shown that diabetics who take metformin have a lower risk of developing cancer.

In the study published Wednesday, the researchers "controlled for glucose levels, which suggest that the effect may be seen beyond the diabetic population," said Jeffrey Engleman, director of the centers for thoracic cancers at Massachusetts General Hospital.

The study showed that metformin activates an enzyme that neutralizes a protein which plays a key role in the growth and survival of cancerous cells in the lung, said Dennis.

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Study Points to the Benefit of Diabetes Drug in Fighting Lung Cancer in Mice

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