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Study Identifies Body's Natural Painkillers

by Medindia Content Team on  December 19, 2007 at 5:54 PM Research News   - G J E 4
Study Identifies Body's Natural Painkillers
A new study in mice has shown that getting rid of an enzyme called c-Kit increases pain tolerance. Gary Lewin and colleagues at the Max Delbrück Centre for Molecular Medicine in Berlin, Germany, said that the new finding could lead to the development of a new class of painkillers that work by blocking the enzyme.
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The skin holds more than a million 'nociceptors', or bare nerve endings, around half of which fire in response to pain, reports New Scientist.

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During the study, researchers found that mice which cannot make c-Kit took 40 per cent longer to jerk their paw away from a hot infrared beam.

Also, the beam had to be 6 degrees Celsius hotter to make the nociceptors fire.

On the contrary, in normal mice, c-Kit seems to be what makes inflamed skin feels pain more easily.

Source: ANI
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