Medindia

X

Study: IMPACT Results Show Potential Cancer Treatment

by Rajshri on  April 20, 2010 at 8:36 PM Cancer News   - G J E 4
 Study: IMPACT Results Show Potential Cancer Treatment
During the second plenary session of the 25th Anniversary EAU Congress in Barcelona, Dr. Neal Shore (GB) presented for the first time in Europe the updated results of the study "Sipuleucel-T Active Cellular Immunotherapy for Metastatic, Castration-Resistant Prostate Cancer: results from the IMPACT trial."
Advertisement

"This study shows a potential new treatment paradigm in oncology and is the first active immunotherapy to demonstrate improvement in overall survival (OS) for metastatic CRPC (castrate-resistant prostate cancer)," said Shore

Advertisement
Shore said the effect was upheld with longer follow-up and that the majority of the most common adverse events occurred within one day of infusion, were mild and moderate in severity ( < Grade 2) and resolved within one to two days.

"Response rate and time to progression may not be appropriate endpoints in therapeutic vaccine trials," Shore said, adding that the use of immune therapy earlier in the natural history of the disease requires further study.

Sipuleucel-T is an investigational autologous active cellular immunotherapy for treatment of prostate cancer. The randomised, double-blind, placebo controlled phase III trial in CRPC showed a significant increase in OS. Adverse events reported more commonly in the sipuleucel-T than the placebo arm included chills, pyrexia, headache, influenza- like illness, myalgia, hypertension, hyperhidrosis and groin pain.

Other findings indicate that prognostic factors were well-balanced with the median predicted OS of patients in the sipuleucel-T and placebo arms were 20.3 and 21.2 months, respectively, using the Halabi model (2003).



Source: Eurekalert
RAS
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

Advertisement
View All