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Study Finds Reason Why Women Suffer from Migraines Than Men
For every man with a migraine, three women are struck by the severe headaches that often come with nausea, sensitivity to light and sound, and aura.
The research, by boffins at University of California Los Angeles (UCLA), has now suggested that this happens because women have a faster trigger than men for activating waves of brain activity thought to underlie migraines.
As a part of the study, lead researchers Dr. Andrew Charles, director of the Headache Research and Treatment Program in the UCLA Department of Neurology; Dr. Kevin C. Brennan, a clinical and research fellow in Charles' lab; and colleagues used a mouse model to discover a big difference between males and females with regard to a phenomenon called cortical spreading depression (CSD), which is thought to be a chief culprit in causing migraines.
Dr. Brennan, working in Dr. Charles' lab, used imaging techniques to visualize the initiation and spread of CSD in anaesthetized male and female mice.
Female mice showed a significantly lower threshold for CSD when compared with males. In other words, it was much easier to evoke the waves of brain activity believed to underlie migraine in females than it was in males.
'The results were very clear. The strength of the stimulus required to trigger CSD in males was up to two or three times higher than that required to trigger the response in females,' said Charles.
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