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Study Finds Anesthesia Increases Risk of Developing Alzheimer's-like Symptoms
Spanish researchers coordinated by Doctors Maria Angeles Mena and Justo Garcia de Yebenes, from CIBERNED (Centro de Investigacion Biomedica en Red de Enfermedades Neurodegenerativas), found that anaesthesia is safe for normal mice but potentially harmful for mice with mutations of the amyloid precursor protein (APP).
The findings suggest a possible mechanism of developing Alzheimer.
Some epidemiological studies have shown an increased prevalence of AD in patients undergoing anaesthesia and surgery.
"Before surgery requiring anesthesia, it may be ideal to know the genetic background of the patients so that the drugs used and the pattern of anaesthesia may be personalized accordingly,' said de Yebenes.
The linkage between the repetitive use of isoflurane anaesthesia and the development of AD changes in mice with mutations indicates the advisability of testing for genetic risk factors for AD in patients prior to surgery.
The researchers concluded that anaesthesia is safe for normal mice but risky for asymptomatic carriers of mutations, which produce AD.
The research has been based on the application of anaesthesia twice a week during three months in normal mice and in mice with mutations (7-10 months old) that produce AD (known as APPswe).
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More News on: Dental Anesthesia, Spinal and Epidural Anesthesia, Local Anaesthesia, General Anesthesia, Anaesthesia - History, Anaesthesia - History and Origins, Post operative Complications
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