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Study Confirms Long-term Benefits of Morphine Treatment in Infants

by VR Sreeraman on  November 5, 2008 at 12:45 PM Research News   - G J E 4
 Study Confirms Long-term Benefits of Morphine Treatment in Infants
Administration of preemptive morphine prior to a surgery in infancy tends to block the long-term negative consequences of pain in adult rodents, confirms a new study.
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Researchers at Georgia State University have been the first to prove that infants who were not administered pre-emptive morphine before a painful procedure will need more morphine in adulthood to modulate their pain.

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The study, which has been published online in Pediatric Research, had divided a group of rat pups into two, with one group receiving an injection of morphine sulfate on the day of birth while the other received a saline injection prior to inducing inflammation.

While the former group of rodents behaved normally after getting identical procedures during a 60-day period, the latter showed significant increases in pain sensitivity and were resistant to the pain relieving effects of morphine in adulthood.

According to Anne Z. Murphy, Ph.D., a GSU Professor of Neuroscience and member of the Center for Behavioral Neuroscience, and graduate student Jamie LaPrairie, the results confirmed the long-term behavioural benefits.

Murphy said: "These results suggest that there are long-term benefits of providing all newborns with some sort of pain relieving medicine prior to the initiation of an invasive procedure."

Source: ANI
SRM/SK
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