The meta-analysis of five major breast cancer trials has confirmed that a combination therapy of chemotherapy and antibody trastuzumab chemotherapy improves survival in women with operable HER-2 positive breast cancer.
Issa Dahabreh from the University of Athens conducted the meta-analysis of 5 trials involving more than 13,000 women whose breast cancer was amenable to surgery, and found that it helps improve their chances.All the trials compared disease-free survival, overall survival and the risk of locoregional and distant recurrence of breast cancer in women given adjuvant chemotherapy alone or chemotherapy plus trastuzumab, after breast surgery.
Up to a quarter of all breast cancers express large amounts of the HER2 protein or carry multiple copies of the HER2 gene. Those cancers tend to be associated with aggressive disease, a higher likelihood of recurrence and a decreased response to treatment.
Trastuzumab is a monoclonal antibody that directly targets part of the HER2 tyrosine kinase receptor.
The results showed that combining trastuzumab with chemotherapy results in a 34 percent reduction in mortality and a 38 percent increase in disease-free survival, Dahabreh said.
Those survival benefits were accompanied by decreases in the risk of both locoregional and distant recurrences of the cancer.
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The results were reported at the ESMO (European Society for Medical Oncology Conference) at Lugano.
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LIN/M