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Structural Changes In Brain's Cortex Raises Depression Risk: Study
Myrna Weissman, Ph.D., professor of epidemiology in psychiatry, led the research at Columbia University Medical Center and the New York State Psychiatric Institute.
It was found that people at high risk of developing depression had a 28 percent thinning of the right cortex, the brain's outermost surface, as compared to people with no known risk.
The researchers said that the drastic reduction is similar to the loss of brain matter typically observed in persons with Alzheimer's disease and schizophrenia.
"The difference was so great that at first we almost didn't believe it. But we checked and re-checked all of our data, and we looked for all possible alternative explanations, and still the difference was there," said Peterson.
Peterson said that the thinner cortex might increase the risk of developing depression by disrupting a person's ability to pay attention to, and interpret, social and emotional cues from other people.
Additional tests measured each person's level of inattention to and memory for such cues and it was found that the less brain material a person had in the right cortex, the worse they performed on the attention and memory tests.
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