Stem Cells from Human Fat Tissue to Hunt for and Kill Cancerous Tumours

by VR Sreeraman on  July 5, 2007 at 1:13 PM Genetics & Stem Cells News
RSS Email Print This Page Comment
Font : A-A+

Stem Cells from Human Fat Tissue to Hunt for and Kill Cancerous Tumours
Boffins have developed a new gene therapy by using 'suicide genes' derived from mesenchymal stem cells taken from human fat tissue, which hunt for and kill cancerous tumours.

The study was conducted by a team of researchers led by Cestmir Altaner at the Cancer Research Institute of the Slovak Academy of Sciences in Bratislava.

As part of the study to find a less toxic method than chemotherapy to treat colon cancer, researchers extracted the mesenchymal stem cells from human fat tissue, and after expanding their number in the lab, used a retrovirus vector to insert the gene cytosine deaminase into the cell.

The gene can convert a less toxic drug, 5-fluorocytosine (5-FC), used in chemotherapy, to 5-FU inside the stem cells, and the chemotherapy can then seep out into the tumour, producing a lethal by-stander effect.

Researchers first injected the engineered mesenchymal stem cells, then 5-FC in nude mice, animals with an inhibited immune system, engrafted with human colon cancer.

The study found that tumour growth was inhibited by up to 68.5 percent in the animals, and none of the mice exhibited any signs of toxic side effects.

"The procedure was quite effective even though we applied the stem cells just once. Obviously, repeated treatment will increase the efficacy, as would using this strategy in combination with other treatments," Altaner said.

Researchers suggested that mesenchymal stem cells 'see' a tumour as a damaged organ and migrate to it, and so it might be used as a 'vehicle' for treatment that can find both primary tumours and small metastases.

The findings of the study were published in the July 1 issue of Cancer Research, a journal of the American Association for Cancer Research.

Source: ANI
LIN/M

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions

More News on:

Cholesterol Stem Cells - Cord Blood Stem Cells - Fundamentals Parkinsons Disease Surgical Treatment Ganglion Cysts - Ganglion Wrist Diet Lifestyle and Heart Disease Cysts and Tumours Cholesterol - The Enigma Chemical Liposuction Tumor Markers For Cancer Diagnosis and Prognosis 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Advertisement
Advertisement

Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

News Category

News Archive