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Stem Cells Offers Hope in Treating Alzheimer's
A team of scientists led by Professor Kiminobu Sugaya at the University of Central Florida combined a technique for transplanting stem cells into rats and a newly discovered compound, phenserine.
The researchers say that this arrangement reduces the amount of a plaque that is the main trait of Alzheimers disease. The combination, according to the scientists, activated the regeneration of neurons that are destroyed by Alzheimers and are crucial for healthy brain functions.
Its very exciting. If our success with mice can translate into the human brain, it could give hope to patients and their families, Sugaya said.
Six years ago, Sugaya reported that brain stem cells transplanted into aged rats seemed to become functional neurons and improved age-associated memory loss, with no side effects.
When Sugaya transplanted stem cells into the brains of Alzheimers-model mice, he found that the stem cells did not form any neurons. He found that surplus amounts of the amyloid-precursor protein (APP), which produces a component of the plaques, a hallmark of Alzheimers, prevent stem cells from becoming neurons.
The research team treated Alzheimers-model mice producing human APP with phenserine, which is known to reduce the amount of APP in the brain. The APP level in the brain of treated mice was reduced by up to 50 percent, which would provide best possible conditions for the brain stem cells to become neurons. Under this environment, the research team found that stem cells transplanted into the brain successfully produced neurons.
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More News on: Stem Cells - Cord Blood, Stem Cells - Fundamentals, Parkinsons Disease Surgical Treatment, Genetics and Stem Cells, Bone Marrow Transplantation, Tissue Engineering and Regenerative Medicine, Stem Cells
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