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Stem Cells From Bone Marrow May Help To Treat Skin Disorder
The results of the study showed that when injected into mice with RDEB, these specially selected marrow-derived stem cells diminished the disease process.
"Our data provide the first evidence that a selected population of marrow cells can connect the epidermis and dermis in a mouse model of the disease and offer a potentially valuable approach for treatment of human RDEB and other extracellular matrix disorders. These results provide proof of principle of bone marrow transfer to repair the basement membrane defect in RDEB, and they warrant a clinical trial to assess the safety and efficacy of treatment of human RDEB by means of hematopoietic cell transplantation," said Tolar.
The results indicated that the systemic infusion of wild-type bone marrow cells could provide benefit to other human disorders of the extracellular matrix.
Now scientists are working towards identifying the requirements of bone marrow-derived stem cells capable of efficiently homing to wounded skin and producing an array of extracellular matrix proteins.
Currently, the clinical testing of efficacy of human bone marrow for the treatment of human RDEB is underway to determine whether it is of more substantial benefit than local protein, gene, or cellular therapies currently being investigated by other researchers.
The study was prepublished online in Blood, the official journal of the American Society of Hematology.
Source-ANI
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More News on: Bone Marrow Biopsy, Skin Disorder, Atopic Dermatitis, Sleep Problems in Children, Stem Cells - Cord Blood, Leucopenia, Infantile Cortical Hyperostosis, Stem Cells - Fundamentals, Parkinsons Disease Surgical Treatment, Genetics and Stem Cells
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