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Stem Cell Transplant Patients May be Protected from GVHD by Statins
Mielcarek, first author Marcello Rotta, M.D., a postdoctoral research fellow in the Hutchinson Center’s Clinical Research Division, and colleagues undertook the study because previous research showed that statins have anti-inflammatory effects and have been found to improve control of other inflammatory diseases such as rheumatoid arthritis. Recently, studies using mouse models of stem cell transplantation have shown protection against lethal acute GVHD when the donors and recipients had been treated with statins before transplant.
The exact mechanism of how statins protect against GVHD is not known.
"In the literature, a multitude of possible mechanisms are discussed by which statins may influence immune function," Mielcarek said. "One is cell adhesion – the stickiness of cells that influences how donor T cells that cause GVHD can migrate to certain target tissues. Another is how statins interfere with intracellular signaling in T cells. Statins may dampen the activity of allo-reactive T cells and prevent them from initiating the inflammatory cascade that’s required to cause GVHD."
Grants from the National Institutes of Health and The Dana Foundation funded this research.
Source-Eurekalert
RAS
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